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Ulcerative colitis is a chronic intestinal mucosal inflammation of unknown etiology. Recent epidemiological and molecular studies have provided strong evidence that the inherited predisposition is important in the pathogenesis of chronic inflammatory bowel disease. The model which is consistent with the epidemiological data suggests that ulcerative colitis is related to polygenic diseases. We exprienced a 27-year-old woman with ulcerative colitis combined with follicular thyroid cancer and gestational diabetes mellitus. These diseases were developed consecutively within one and half year. She has family history of thyroid disease and diabetes mellitus. We report this case with a review of literature.