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Purpose: The purpose of this study is to understand the depression of patients for Fibromyalgia Syndrome(FMS) and to identify the factors influencing depression. Method: The instruments used here are Beck Depression Inventory in depression, the Korean Rheumatology Health Association' instruments in Self-Efficacy. Also, Pain and Fatigue was measured by Visual Graphic Rating Scale. The subject of study is 76 outpatients diagnosing FMS from rheumatism specialists at C hospital in D city. The data has been collected from Sep. lst to Sep. 30th in 2001. For the analysis of collected data, frequency analysis, independent t-test, analysis of variance, Pearson's correlation and multiple regression analysis were used for statistical analysis with SAS statistical program. Result: General characteristics showing statistically significant difference in depression were age, education, occupation, gender, exercise and sleep in the patients with FMS. Depression for the patients with FMS has negative correlation coefficients with Self-efficacy and ADL, and positive correlation coefficients with Pain and Fatigue. The suitable regression form resulting from the multiple regression analysis to investigate the influencing factors of depression for the partients with FMS was expressed by y = 50.067 - 0.278χ1 + 1.320χ2 (χ1 : Self-Efficacy χ2 : Fatigue) and R2 = 0.427. Conclusion: The factors influencing on depression of patients for FMS was Self- Efficacy, ADL, Pain, and Fatigue. Further study needs to be done identify methods of overcoming and presentation of depression in FMS.