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저자들은 혈뇨와 단백뇨를 주소로 내원한 31세 여자 경피증 환자에서 임상적으로 고혈압, 신발증이 없으면서 신증후군을 보이고 조직학적으로 신장 혈관의 침범없이 사구체 경화와 반월체 형성이 관찰되는 미만성 반월상 사구체신염의 증례를 경험하였기에 문헌고찰과 함께 보 고하는 바이다.


Inje University College of Medicine, Seoul, Korea Scleroderma is a connective tissue disorder characterized by fibrosis of the skin, vessels and internal organs (gastrointestinal tract, lung, heart, and kidney etc.). Renal involvement in scleroderma has a clinical manifestation from subnephrotic proteinuria to renal crisis accompanied by hypertension, and shows a typical histology of intimal proliferation and fibrinoid necrosis of blood vessel without primary glomerular pathology. We experienced a case of nephrotic syndrome in a 31-old-female patient with sclerodema. But the patient has not showed a clinical feuture of hypertension or renal crisis, moreover, renal biopsy of the patient showed global sclerosis and crescent formation in the glomeruli without vessel involvement. We report this case with a brief review of literature.(Korean J Med 64:91-95, 2003)


Inje University College of Medicine, Seoul, Korea Scleroderma is a connective tissue disorder characterized by fibrosis of the skin, vessels and internal organs (gastrointestinal tract, lung, heart, and kidney etc.). Renal involvement in scleroderma has a clinical manifestation from subnephrotic proteinuria to renal crisis accompanied by hypertension, and shows a typical histology of intimal proliferation and fibrinoid necrosis of blood vessel without primary glomerular pathology. We experienced a case of nephrotic syndrome in a 31-old-female patient with sclerodema. But the patient has not showed a clinical feuture of hypertension or renal crisis, moreover, renal biopsy of the patient showed global sclerosis and crescent formation in the glomeruli without vessel involvement. We report this case with a brief review of literature.(Korean J Med 64:91-95, 2003)