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Most engineering products contain more than one component. Failure occurs either at the connection itself or in the component at the point of attachment of the connection in many engineering structures. The allocation and design of connections such as bolts, spot-welds, adhesive etc. usually play an important role in the structure of multi-components. Topology optimization of connection component provides more practical solution in design of multi-component connection system. In this study, a topology optimization based on density distribution approach has been applied to optimal location of fasteners such as T-shape, L-shape and multi-component connection system. From the results, it was verified that the number of iteration was reduced, and the optimal topology was obtained very similarly comparing with ESO method. Therefore, it can be concluded that the density distribution method is very suitable for topology optimization of multi-component structures.