초록 close

Background and Objectives:Laminins are extracellular matrix proteins localized mainly in basement membranes. Currently membrane molecule (α3β3γ2). It serves as an important adhesion protein for epithelial cells and it also plays an important role in cell migration during tumor invasion and tissue remodeling. This study was designed to investigate the relationship betwen laminin-5 expresion and clinicopathologic variables in oral cavity and oropharynx squamous cell carcinomas using imunohistochemistry. Materials and Method:The expresion of the laminin-5 around tumor cells was determined in 32 oral γ2 chain. Results:St-atistical analysis showed that the frequency of laminin-5γ2 chain expression was corelated with the lymph node metastasis (p<0.05). The poor differentiation of tumor cells, the large tumor size, advanced overall stage and the deep tumor invasion showed high expresion of laminin-5, although it was not significant statisticaly. Conclusion:These results suggest that cervical lymph node metastasis. (Korean J Otolaryngol 2002 ;45 :1179-83)


키워드close