초록 close

Background and Objectives:The etiology and the pathophysiology of nasal polyps are still not definitely known and recently, it is suggested that inflammatory responses involving eosinophils may play a major role. The proces of the infiltration of eosinophils in tissues is explained by the increase of the movement of eosinophils to the inflammatory area and the delay of apoptosis which expressed their anti-apoptotic Bcl-xL genes and pro-apoptotic Bax genes when put in a delayed apoptotic condition. The purpose of this study is to investigate Bcl-xL and Bax expresions of eosinophils in nasal polyps and how allergic rhinitis afect their expressions. Materials and Method:Nasal polyps were obtained from patients with chronic paranasal sinusitis (30 cases) and nasal polyps were divided into two groups, one obtained from the patient with allergic rhinitis (15 cases) and the other obtained from the patient without allergic rhinitis (15 cases). The normal control group consisted of 5 cases of normal nasal mucosa in the inferior turbinate. The imunohistochemical stain was used to detect eosinophils and the cels expressing Bcl-xL and Bax. Results:In nasal polyps, a significant statistical corelation betwen eosinophil numbers and Bcl-xL positive cell numbers was detected. But there was no corelation betwen them in the normal control. The Bax positive cell numbers had a corelation to eosinophil numbers in both the normal control and nasal polyps. And allergic rhinitis did not affect the expression of Bcl-xLin nasal polyps. Conclusion:The authors propose that in eosinophils of nasal polyps, Bcl-xL plays an important role in delayed apoptosis and allergic rhinitis has no efect on the expresion of Bcl-xL and Bax. (Korean J Otolaryngol 2002 ;45 :1152-6)