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Background and Objectives:Fod restriction increases life span, reduces aging rate and affects a wide variety of biolo-gical functions. Neurotransmitter is a substance released from the axon terminal of a presynaptic neuron on excitation, which diffuses across the synaptic cleft to either excite or inhibit the target cell. The nervous system makes use of neurotransmitters for signaling. We investigated the change of imunoreactivity of neuropeptides in olfactory bulb of rat after food restriction. Materials and Method:Of 10-wek old Sprague-Dawley rats used in this study. six rats were killed at the beginning of the (12 g instead of 24 g per day) were killed at 3 days, 1, 2, 4 and 9 weks after food restriction (n=6 per time point). Olfactory bulbs of the rats were cut into 40 μm-thick coronal sections and immunostained. Results:On the layers of glomerular, outer plexiform, gra-nular cell and subependymal zone of olfactory bulb, immunoreactivities of cholecystokinin (CCK), tyrosine hydrolase (TH), and neuropeptide-Y (NPY) eactivities of CCK and TH were increased at 2 weeks of food restriction. However, imunoreactivity of NPY was increased on the only layers of gl-omerular, and granular cell of olfactory bulb at wek 2. After 4th wek, the immunoreactivity of NPY was the same as the control group;after 9th wek, the mmunoreactivity of CCK and TH were the same as the control group. Conclusion:Our results demonstrated that CCK, TH, and NPY could be expresed in different manners on the layers of olfactory bulb of rat (Korean J Otolaryngol 2002;45:579-84)