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Background and Objectives:Lymph node metastasis is believed to be the single most important prognostic factor in the head evaluated the relationship between cervical nodal status and several parameters, such as microvesel density, p53, Ki67, and DNA ploidy, and compared it with the conventional clinical parameters including histologic grade of the tumors. Materials and Method:This study group included 26 specimens from the primary sites of patients who were diagnosed with squamous cell cancers of the head and neck. Immunohistochemstry and DNA flowcytometry were performed at almost the same sections of the thelial cells positively stained with CD-31 under the magnification filed power of 200 by two investigators; the cell number was determined by taking the average of the highest values of thre counts made by each investigator. Immunohistochemical staining with Ki67 and p53 were also done to evaluate the cellular proliferation of tumors and the overexpresion of mutated tumor sup-presor gene. DNA flowcytometry was performed to evaluate the ploidy and proliferation index. These results were compared and analyzed with clinical parameters. Results:this study. However, the microvessel density of the laryngeal cancers showed a statisticaly significant relationship with the cervical nodal metastasis (p=0.045). Conclusion:The microvessel density may have a corelation to the lymph nodal metastasis in the head and neck squamous cell cancer and may be regarded as an additional prognostic factor for planing treatment. (Korean J Otolaryngol 2002;45:990-7)