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Mucosa-associated lymphoid tissue(MALT) is a specialized form of lymphiod tissue that may be acquired at sites in response to chronic inflammation. MALT lymphoma is a type of low-grade, B-cell lymphoma within the spectrum of non-Hodgkins extranodal lymphomas, and may arise within several sites in the head and neck. Because of the diferences in the natural history, prognosis, and therapy of MALT lymphoma and other lymphomas, the immunohistochemical and molecular biology studies should be considered in the diagnosis of MALT lymphoma in cases where atypical lymphoid infiltrates into the head and neck. We present a case of advanced staged multifocal MALT lymphoma, which has disseminated into the bone marrow, involving mucosal sites of the ethmoid sinus, hard palate and chek, but not the gastrointestinal tract, with a review of relevant literature. (Korean J Otolaryngol 2002;45:926-9))