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Background and Objectives:Fulminant invasive fungal sinusitis (IFS) is an aggressive, destructive disease most commonly o determine its prognostic factors. Materials and Method:Fiften cases of invasive fungal sinusitis were retrospectively reviewed. Prognosis was analyzed according to predisposing factors including the underlying disease, the extent of disease, the mycotic species, and treatment modalities. Results:Overall 5-year survival rate of the patients with IFS was 60%. There was significant survival gain in the group for which underlying disease was well controlled (p= 0.04). There was no diference in survival in terms of mycotic species and extent of disease at presentation. No statistically significant diference in survival was observed betwen the conservative surgery and the radical surgery group. Conclusion:Survival is usually determined at the very early period of treatment. The most important prognostic factor is not the surgical modalities including wide surgical resection or conservative debridement, but the optimal control of underlying disease. (Korean J Otolaryngol 2003 ;46 :841-5)