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Background and Objectives:To evaluate the relationship of the clinicopathologic findings in squamous cell carcinomas of the (MMP-2) by immunohistochemical stain. Materials and Method:Twenty-five patients with squamous cell carcinomas of the oral tongue were clasified as their tumor stage, lymph node metastasis and histopathological grade and their parafin-embedded surgical specimens were investigated by imunohistochemical analysis using monoclonal E-cadherin antibody and MMP-2 antibody. Results:There was not any significant corelation betwen the expresion of E-cadherin and the tumor stage (p>0.05), but it showed significantly reduced expression of E-cadherin in moderately or poorly differentiated carcinoma (p= 0.034). The expression of MMP-2 increased significantly with respect to the metastasis of the cervical lymph node in early carcinoma (p= 0.045) but it was not corelated with primary tumor size or histological diferentiation (p>0.05). We cannot find any inverse relationship Conclusion:The expresion of E-cadherin and MMP-2 may be related the disease processes of squamous cell carcinomas of the oral tongue and will provide the possibility of the its biochemical parameters. (Korean J Otolaryngol 2003 ;46 :686-91)


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