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Background and Objectives:Recurrent laryngeal papillomatosis (RRP) have been divided into juvenile or aggresive forms, and adult or non-agresive forms. This study attempted to characterize these two forms of RRP in our series and to detect human papilloma virus (HPV) using polymerase chain reaction (PCR). Materials and Method:Authors reviewed the re-cords of 60 patients treated for RRP over a 16-year period from 1983 to 1999 at the Department of otolaryngology, Pusan state, number of operation, agressivenes, outcome of treatment and complications after operation. Twenty-thre parafine-mbedded tissues were selected to PCR using type-specific primer pairs. Results:1) Subglottic extension, tracheotomy, time of operation and agresivenes were more comon in juvenile form than the adult form. 2) The multiple type was also co-mon in the adult form. 3) Non-agresive and single types showed better response for treatment. 4) There are no signifi-cant differences of cure rate acording to age and treatment modality, but preoperative α-interferon therapy showed more effective in the case of compromised airway. 5) HPV type 6, 11 in 10 cases (43.5 %) were detected out of 23 cases. Most detected cases were non-improvement group. Conclusion:The significant difference of treatment results are found in com-parison betwen agresive and non-agresive forms and α-interferon may be an effective therapy for aggressive respira-tory papillomatosis. HPV subtype may be related to the prognosis factor. (Korean J Otolaryngol 2002;45:69-75)