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Backgrounds and Objectives:While it has been reasonably well demonstrated that allergy is a risk factor for patients of otitis media with effusion (OME)inflamatory reactions, there have been no reports about the presence of other Th2 cytokines in the middle ear efusions of OME patients except for IL-4. The aim for this study was to determine whether Th2 cytokines, IL-5, IL-10 and IL-13, were present in the midle ear efusions, and whether these cytokines were present in higher concentrations in the efusions of allergic patients than of non-allergic patients. Materials and Method:Thirty ears of twenty nine patients with persistent OME were assayed for the (ELISA). Ten of these patients, which are 11 ears, were confirmed allergy positive by multiple allergosorbent test (MAST). The statistical diferences in the positive rates of each cytokines betwen the allergy and the non-allergy groups were asesed by χ2 test or Fishers exact test, and the statistical diferences in the measured concentrations of each cytokines betwen the two groups were asesed by Man-Whitney U test. Results:The positive rates of the levels of IL-10 and IL-13 in the non-allergy group were significantly higher than in the allergy group. Conclusion:The higher levels of IL-10 and IL-13 of the non-allergy group suggest that more active anti-inflammatory cellular responses exist in the middle ear of the non-alergic patients with OME than of the allergic patients, or that at least the diferent inflamatory processes exist betwen the two groups with regard to the pathogenesis of OME. (Korean J Otolaryngol 203 ;46 :459-63)


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