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Background and Objectives:It has been known that imune reaction plays important roles in the pathogenesis of otitis media with efusion (OME)changes of middle ear mucosal inflammation induced by lipopolysacharide (LPS) following administration of imunosuppres-sive agent, Cyclosporin A (CsA) in experimental animals. Materials and Method:35 μl LPS was injected into the midle ears of 30 rats. These rats were divided into groups of 10, each receiving CsA, Dexamethasone, and no treatment, respectively, daily. Five rats from each gr Results:Both the CsA-treated and the steroid-treated groups showed lesser inflammatory changes than the untreated groups, however, there were no significant differences betwen the CsA-treated and the steroid-treated groups. Both on day 2 & day 6, the CsA-treated group showed a decrease of mucosal metaplasia and secretory epithelium, compared with the untreated and steroid-treated group. Conclusion:The results suggest that CsA may be effective in decreasing inflammation with particular significance in mucosal mataplasia and the secretion of effusion in OME. (Korean J Otolaryngol 203 ;46 :269-75)