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Background and Objectives:nce. However, the contribution of altered ion transport across the epithelial cells in rhinovirus-induced alteration in mucociliary clearance has not been studied yet. Thus, we aimed to investigate the effect of rhinovirus infection on the electrical property of airway epithelial cells. Materials and Methods:Tracheal mucosae were harvested and digested with protease. The epithelial cells thus obtained were cultured in air-liquid interface method. Rhinvovirus-16s were infected for 1 hour on the epithelial cells t was measured by Using chamber technique. The electrical properties of control and infection groups were compared. Results:The change in the transepithelial resistance in the control group was 240 Ω.cm2, while it was 263 Ω.cm2 in the RV infected epithelium. The baseline short circuit curent was 6.3 μEq.cm-2.h-1 in the control group and 7.2 μEq.cm-2.h-1 in the RV infected group. The f-ferent significantly in both groups. Conclusion:The results of this study indicated that rhinovirus infection in the airway epith-elial cells does not afect the electrical property, which reflects the function of ion channels in the epithelial cells. (Korean J Otolaryngol 2003 ;46 :211-5)