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Background and Objectives:This study was conducted to investigate the anticancer effect of photochemotherapy in vitro using a photosensitizing agent (Photogem) and a laser therapy (632 nm diode laser). Materials and Method:mous cell carcinoma cell (SNU-1041) was treated to laser therapy for various irradiation times, laser powers, and interval times. The treated cell was analyzed by MT assay, DAPI staining to see apoptosis. Results:The viability of cells was dec-reased with the increasing of the laser irradiation time and the laser power. No significant difference in cel viability was noted by various interval time. Increasing apoptosis was observed by increasing concentration of Photogem and increasing lasering time by DAPI staining. :This study demonstrated anticancer efect of photochemotherapy using Pho-togem and 632 nm diode laser. Apoptosis was observed in the proces of cancer cell death. (Korean J Otolaryngol 2002;45: 884-8)


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