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Background and Objectives:asthma have showed somewhat diferent mucosal appearance and pathology, compared to those without asthma. We investigated histopathological features of these patients. Subjects and Method:19 sinusitis patients with asthma who had undergone endo-scopic sinus surgery from April, 1995 through September, 1997, and 53 patients without asthma who had undergone surgery from January, 1997 through July, 1997 were evaluated. We compared the following 7 parameters of sinus mucosal histopa-thology betwen the asthma and non-asthma group by reviewing histopathological slides:basement membrane thickening, goblet cell hyperplasia, subepithelial edema, submucous gland formation, eosinophilic infiltration, lymphocyte infiltration, OMC CT findings, and presence of allergy, which might affect the sinus mucosal pathology. Results:There revealed no statistical difference betwen two groups on presence of allergy, preoperative polyposis, and OMC CT scores. However, the asthma group showed significant basement membrane thickening, goblet cell hyperplasia, and eosinophilic infiltration, which was statisticaly significant. No difference was found between subepithelial edema, submucous gland formation, lymphocyte in-filtration, and polymorphonuclear leukocyte infiltration. Conclusion:Significant histopathological features such as basement ;however, there were no differences owing to the presence of alergy or the extent of preoperative disease. Adequate preoperative manage-ment, close attention during surgery and careful folow-up would be necessary. (Korean J Otolaryngol 2002;45:878-83)