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Background and Objectives:Various host and tumor parameters, particularly the tumor size and lymph node metastasis have been studied in an attempt to evaluate and decide the optimal treatment of the patients with head and neck carcinomas. Moreover, it has been recognized that prognostic parameters can be useful for the evaluation of biological behaviors of malignancy. The p53 is a tumor suppresor gene and cyclin D1 is a cell cycle regulator, esential for G1 phase progresion. Cathepsin D is a lysosomal aspartyl endopeptidase which degrades the extrstill controversy in their clinical meanings in sinonasal malignant tumors. The purpose of this study is to assess the roles of p53, cyclin D1 and cathepsin D in sinonasal tumorigenesis. Materials and Method:27 inverted papilloma (IPs), 5 IPs as-sociated with malignant transformation, and 16 squamous cell carcinoma tissue specimens were investigated by imunohis-tochemical staining for p53, cyclin D1, and cathepsin D. Clinicopathologic values were compared with the incidence of p53, cyclin D1, cathepsin D expresion in sinonasal malignant tumors. Results:p53/cyclin D1 expresions were increased as (p<0.05). No significant corelations were found among p53, cyclin D1, cathepsin D and other clinicopathologic factors. Conclusion:These data sugest that expresions of p53, cyclin D1 and cathepsin D may play an important role in the tumorigenesis and progresion of sinonasal malignant tumor sequence. Also, it is sugested that p53/cyclin D1 expresions may be useful variables for the prognostic asesment of si-nonasal malignant tumors. However, it is not enough conclude so based on this result alone. Further studies, such as using or prognosis of sinonasal malignant tumors. (Korean J Otolaryngol 2002;45:771-6)


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