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Background and Objectives:The clasic imunotherapy has the inconvenience and the risk of anaphylaxis. Recent reports revealed that imunostimulatory DNA sequences (CpG motif, ISS-ODN) have been shown to act as strong Th1 response-inducing adjuvants and DNA based vaccination might be an effective therapeutic option for the treatment of allergic disease. In our study, we investigated whether ISS-ODN have anti-allergic efect in the mouse rhinitis model of Dermatophagoides farinae (Der f), the most common allergen in Korea. Materials and Method:C57BL/6 mice were sensitized with crude extract of Der f extract. After injection of ISS-ODN, several parameters of allergic response were evaluated. Results:In-jection with ISS-ODN supressed itching symptom, eosinophilic infiltration into nasal mucosa and the splenic T cell pr-oliferation after Der f allergen challenge in the murine model of allergic rhinitis. However, injection with ISS-ODN did not show a detectable Der f-specific IgE suppresion. Conclusion:in the allergic rhinitis model of Der f allergen. House dust mite allergy can be reduced by the injection with ISS-ODN. (Korean J Otolaryngol 2002;45:462-6)


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