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Background and Objectives:The iner ear is an organ used for hearing and balance. For its normal function, the iner ear balance, and they have not yet been clearly defined. TonEBP is the protein that binds tonicity-responsive enhancer elements in the osmoprotective gene, which elevates the compatible osmolytes, which in turn induces cell survival in hypertonic co-ndition. The aim of this study was to elucidate if there is an osmoregulatory mechanism in cochlea. Material and Method:The localization of TonEBP in the cochlea of male Sprague-Dawley rats was studied by immunohistochemistry with an anti rabbit polyclonal anti-rat TonEBP antibody. Results:TonEBP was expresed at outer hair cells, Deiter cells, spiral ligaments, Conclusion:TonEBP in cochlea is one of the proteins involved in elucidating cell survival in changed tonicity during iner ear homeostasis. (Korean J Otolaryngol 2002;45:439-44)