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Background and Objectives:eficacy, however, is limited due to the occurrence of sensorineural hearing loss. Little is known about the course of hearing loss after cessation of cisplatin administration. We observed the cochlear duct morphology with normal and cisplatin treated animals. Materials and Methods:Healthy rats (strain Sprague-Dawly, weighting 80-100 mg) were used for all experim-ents. Total 15 rats were selected. They were divided into two groups, a treated group and a control. Four survival groups (n=3, respectively)10, 20 days. Except for the normal control (n=3), twelve animals were treated with cisplatin by daily I.P. injection of 1.5 mg/kg for 8 consecutive days. Results:One day after cessation of cisplatin administration, outer hair cells (OHCs) loss and stria vascularis were degenerated especialy in the basal turn. At 4, 10, 20 days, the OHCs and stria vascularis morphology of the survival group were similar to those of the survival group at one day. Conclusion:icity is predominantly involved in the basal turn of cochlear duct. This finding was significantly correlated with high frequency hearing loss of cisplatin ototoxicity. (Korean J Otolaryngol 2002;45:538-43)