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Background and Objectives:wounds and fractures. By contrast, uncontrolled angiogenesis can often be pathological. Vascular remodelling could there-fore play an important role in the growth proces of solid tumors. The aim of this study was to detect the expresion of platelet-derived endothelial cell growth factor (PD-ECGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF), and investigate the correlation between these factors. Also, we studied the relationships between the larynx. Materials and Method:The authors examined the expression of three angiogenic factors in specimens of laryngeal squamous cell carcinoma (n=17). The mRNA expressions of angiogenic factors were detected by the semi-quantitative re-verse transcription-polymerase chain reaction (RT-PCR). Statistics were analysed using the Fisher's exact test, the Wilcoxon signed rank test, and the Spearman correlation coefficiency. Results:PD-ECGF and bFGF were significantly higher in the involvement. The expression of more than one factor was significantly related with stages III and IV cancer. PD-ECGF and VEGF were related with each other. Conclusion:The authors sugest that angiogenic factors, especially, PD-ECGF and bFGF, may be used as prognostic factors for the squamous cell carcinoma of larynx. (Korean J Otolaryngol 2002;45:488-94)