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To determine whether or not bisphenol A affects the immune system, female ICR mice were treatedbisphenol A(BPA) orally at the doses of 100, 500 and 1,000mg/kg for 30 consecutive days. Four days beforeenumerating plaque-forming cells (PFCs) mice were immunized intraperitoneally with sheep red blood cells(SRBCs). The spleen cellularity and PFC/spleen were significantly reduced by 30--2, the lymphocyteproliferation ex vivo was not significantly suppressed by BPA. Our present results indicated that 30-dayexposure of mice to BPA might have mild immunotoxic potential.