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Bisphenol A shares similarities in structure, metabolism and action with DES, a known human teratogen andcarcinogen. Bisphenol A, a monomer of polycarbonate and epoxy resins, has been detected in canned food andhuman saliva. The purpose of the this study was to evaluate the cytotoxicity, cell proliferation of bisphenol Ain the presence of a rat liver S9 mix, contaning cytochrome P450 enzymes, and Cu (II). In the present study,Bisphenol A in combination with Cu(II) exhibited a enhancement in cytotoxicity which were inhibited by freeradical scavengers. The content of malondialdehyde, an end product of lipid peroxidation, was also found toincrease with concentration of bisphenol A. Also, we examined the change of CuZn-SOD, Mn-SOD, catalaseand GPx activities in the MCF-7 cells exposed to bisphenol A. The activities of CuZn-SOD, GPx, catalasewere found to decrease with bisphenol A concentration. Meanwhile, the activity of Mn-SOD was unchanged.This indicated that elevated oxidative stress caused by imbalance between the production and removal of freeradicals occurred in cells.