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연구목적정신분열병의 약물치료를 비롯한 정신과 치료에 있어서 다양한 임상적 결정을 내릴 때에는 여러 요인들이 영향을 끼치며, 이에 따라 진료 내용에 상당한 변이가 나타날 수 있다. 보다 합리적인 진료를 지향하기 위해서는 대다수 병원의 평균적 진료 실태와 함께 다양성의 정도를 살펴보고, 각 병원 고유의 특수성에 대해 분석해보는 것이 필요하다. 본 연구는 이에 현재 국내에서 행해지고 있는 정신분열병의 치료가 어느 정도의 변이를 보이고 있는 지에 대해 살펴보고자 하였다.


ObjectivesConsiderable variations in the contents of clinical practice are the natural consequences of the fact that so many factors can have influences on each clinical decision making processes in the psychiatric treatment, let alone the pharmacotherapy of schizophrenia. To attain the goal of rational treatment, it is needed to examine the actual contents of clinical practices and the degree of variations among diverse hospitals. In addition, it is also needed to look into the unique situations in which each hospital is situated. For this purpose, this study tried to investigate the degree of variations in several aspects of the treatment of schizophrenia with atypical antipsychotics currently practiced in Korea.MethodsThis study is based on the data from RODOS (Risperidone Olanzapine Drug Outcome Study) in Korea. This study had been designed as a multi-center naturalistic study, therefore, had many advantages for the survey study of actual clinical practices. The subjects of the study were the in-patients who had been given risperidone or olanzapine for the control of their psychotic symptoms. Clinical data had been gathered by retrospective chart review. The degree and the characteristics of the variations were examined by comparing the patient-characteristic variables and the treatment-related variables among each hospital.