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연구목적 : 알코올을 섭취하고 8~16시간 후에 오는 불쾌한 효과를 일반적으로 숙취라고 한다. 본 연구자들은 정상인에서 실험적으로 숙취를 유도한 후 알코올 복용 전과 숙취 상태의 cytokine 생성능을 조사하여 숙취 상태와 면역계와의 연관을 알아보았다.


Object : A hangover is characterized by the constellation of unpleasant physical and mental symptoms that occur 8-16hr after alcohol drinking. We evaluated the effects of experimentally induced alcohol hangover on immune functions by measurement of cytokine production.Methods: A total of 13 normal adults males participated in this study. They did not have any previous histories of psychiatric disorder & medical disorder. We defined the experimentally induced hangover condition as 13 hours after drinking high doses of alcohol (2.0g/kg of body weight). Venous blood was taken before the alcohol drinking & during experimentally hangover conditions. Monocyte was separated and stimulated with phytohemagglutinin. Cytokine production was measured by ELISA for IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12, INF-γ, TNF-α.