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The heartwood of Caesalpinia sappanL.(Leguminosae) has been used to activate blood flow, remove bloodstasis, reduce swelling and relieve pain in Korean folk medicine. In this study, the antioxidant effects of thiscrude drug and its hepatoprotective activity on CCl4-induced liver injury in rats were evaluated. The levels of4 treatment, were recov-ered by this crude drug. It is suggested that Caesalpinia sappan L. have antioxidant effect. The increased levelsof glutamic oxaloacetic transaminase(GOT) and glutamic pyruvic transaminase(GPT) by CCl4 were also reco-vered by treatment with this crude drug. These results can be attributed to the agent antioxidant and memb-rane-stabilizing actions.