ABSTRACT

This study was conducted to investigate the anti-aging effects and cell toxicity of water extracts obtained from Ailanthi radicis cortex at 95℃. The amount of total flavonoid and polyphenol compounds was 4.80 mg/g and 136.89 mg/g, respectively. The astringent effect as a measure of pore tightening activity of the Ailanthi radicis cortex extract was 36.34% at 100 μg/mL. The tyrosinase inhibition as a measure of whitening activity was 53.20% at a concentration of 1,000 μg/mL. The collagenase and elastase inhibitory activities as a measure of anti-wrinkle activity were 48.97% and 18.02% at 1,000 μg/mL, respectively. Cell viability, as determined using the MTT assay, Ailanthi radicis cortex water extract showed no toxicity toward RAW264.7 macrophages and HaCaT keratinocytes. The Ailanthi radicis cortex water extract promoted the synthesis of procollagen type-1 and collagen type-1 at concentration dependent manner. These results suggested that the water extract from the Ailanthi radicis cortex have anti-aging properties and could be used as a natural source for development of functional cosmetics.

KEYWORD

Ailanthi radicis cortex, Anti-aging, Astringent effect, Anti-wrinkle, Cytotoxicity

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